Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00080530" target="_blank" >RIV/00159816:_____/24:00080530 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135902
Result on the web
<a href="https://www.nature.com/articles/s41531-024-00656-8" target="_blank" >https://www.nature.com/articles/s41531-024-00656-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41531-024-00656-8" target="_blank" >10.1038/s41531-024-00656-8</a>
Alternative languages
Result language
angličtina
Original language name
Coupling between beta band and high frequency oscillations as a clinically useful biomarker for DBS
Original language description
Beta hypersynchrony was recently introduced into clinical practice in Parkinson's disease (PD) to identify the best stimulation contacts and for adaptive deep brain stimulation (aDBS) sensing. However, many other oscillopathies accompany the disease, and beta power sensing may not be optimal for all patients. The aim of this work was to study the potential clinical usefulness of beta power phase-amplitude coupling (PAC) with high frequency oscillations (HFOs). Subthalamic nucleus (STN) local field potentials (LFPs) from externalized DBS electrodes were recorded and analyzed in PD patients (n = 19). Beta power and HFOs were evaluated in a resting-state condition; PAC was then studied and compared with the electrode contact positions, structural connectivity, and medication state. Beta-HFO PAC (mainly in the 200-500 Hz range) was observed in all subjects. PAC was detectable more specifically in the motor part of the STN compared to beta power and HFOs. Moreover, the presence of PAC better corresponds to the stimulation setup based on the clinical effect. PAC is also sensitive to the laterality of symptoms and dopaminergic therapy, where the greater PAC cluster reflects the more affected side and medication "off" state. Coupling between beta power and HFOs is known to be a correlate of the PD "off" state. Beta-HFO PAC seems to be more sensitive than beta power itself and could be more helpful in the selection of the best clinical stimulation contact and probably also as a potential future input signal for aDBS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/GA21-25953S" target="_blank" >GA21-25953S: Subcortical nuclei and cortical functions – insight from the deep brain stimulation perspective</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
npj Parkinsons Disease
ISSN
2373-8057
e-ISSN
2373-8057
Volume of the periodical
10
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
40
UT code for WoS article
001169223800001
EID of the result in the Scopus database
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