The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00081380" target="_blank" >RIV/00159816:_____/24:00081380 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00138595 RIV/00216208:11110/24:10487512 RIV/00064211:_____/24:W0000039 RIV/00064203:_____/24:10487512
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0304419X24001471?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304419X24001471?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbcan.2024.189216" target="_blank" >10.1016/j.bbcan.2024.189216</a>

Result language
angličtina
Original language name
The interplay between microbiome and host factors in pathogenesis and therapy of head and neck cancer
Original language description
Heterogeneous cancers that lack strong driver mutations with high penetrance, such as head and neck squamous cell carcinoma (HNSCC), present unique challenges to understanding their aetiology due to the complex interactions between genetics and environmental factors. The interplay between lifestyle factors (such as poor oral hygiene, smoking, or alcohol consumption), the oral and gut microbiome, and host genetics appears particularly important in the context of HNSCC. The complex interplay between the gut microbiota and cancer treatment outcomes has also received increasing attention in recent years. This review article describes the bidirectional communication between the host and the oral/gut microbiome, focusing on microbiome-derived metabolites and their impact on systemic immune responses and the modulation of the tumour microenvironment. In addition, we review the role of host lifestyle factors in shaping the composition of the oral/gut microbiota and its impact on cancer progression and therapy. Overall, this review highlights the rationality of considering the oral/gut microbiota as a critical determinant of cancer therapy outcomes and points to therapeutic opportunities offered by targeting the oral/gut microbiota in the management of HNSCC.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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