Pathogenesis of euglycemic ketoacidosis associated with SGLT2 inhibitors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00081432" target="_blank" >RIV/00159816:_____/24:00081432 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00136887
Result on the web
<a href="https://aimjournal.cz/artkey/aim-202402-0002_pathogenesis-of-euglycemic-ketoacidosis-associated-with-sglt2-inhibitors.php?back=%2Fsearch.php?query%3DPost-operative%2Bsleep-disordered%2Bbreathing%2Bwith%2Bdifferent%2Banesthesia%2Btechniques%253A%26sfrom%3D90%26spage%3D30" target="_blank" >https://aimjournal.cz/artkey/aim-202402-0002_pathogenesis-of-euglycemic-ketoacidosis-associated-with-sglt2-inhibitors.php?back=%2Fsearch.php?query%3DPost-operative%2Bsleep-disordered%2Bbreathing%2Bwith%2Bdifferent%2Banesthesia%2Btechniques%253A%26sfrom%3D90%26spage%3D30</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.36290/aim.2024.018" target="_blank" >10.36290/aim.2024.018</a>
Alternative languages
Result language
angličtina
Original language name
Pathogenesis of euglycemic ketoacidosis associated with SGLT2 inhibitors
Original language description
Euglycemic ketoacidosis associated with SGLT2 inhibitors, also referred to as gliflozins, is a rare but potentially fatal clinical entity characterized by metabolic acidosis with normal or only mildly elevated glycemia, predominantly in patients with type 2 diabetes mellitus. In addition to ketoacidosis, hyperchloremic acidosis may also contribute significantly to metabolic acidosis. Relative hypoglycemia induced by gliflozins and concomitant stress condition lead to decreased insulin level and increased glucagon, cortisol, and catecholamines, which stimulates ketogenesis. At the same time, gliflozins induce complex renal metabolic dysfunction, in particular impaired renal elimination of acids and renal ammoniogenesis, resulting in hyperchloremic acidosis. In patients treated with gliflozins, acid-base balance and ketonemia should be checked in a timely manner when their condition worsens. Treatment of acidosis consists of discontinuation of gliflozin and administration of insulin at a dose sufficient to suppress ketogenesis. Because of the risk of acidosis, gliflozins should be discontinued at least 3 days before elective surgery and resumed only after stabilization and reliable restoration of oral intake. Similarly, gliflozins should be discontinued in most hospitalized nonsurgical patients with risk factors for the development of acidosis, such as in patients with acute infection, acute heart disease, stroke, fasting before examination, or alcohol abuse.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30223 - Anaesthesiology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anesteziologie a intenzivní medicína
ISSN
1214-2158
e-ISSN
1805-4412
Volume of the periodical
35
Issue of the periodical within the volume
2
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
98-103
UT code for WoS article
001284895400003
EID of the result in the Scopus database
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