Extracellular histones profiles of pediatric H3K27-altered diffuse midline glioma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00081673" target="_blank" >RIV/00159816:_____/25:00081673 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s40291-024-00754-6" target="_blank" >https://link.springer.com/article/10.1007/s40291-024-00754-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s40291-024-00754-6" target="_blank" >10.1007/s40291-024-00754-6</a>

Result language
angličtina
Original language name
Extracellular histones profiles of pediatric H3K27-altered diffuse midline glioma
Original language description
yocardial deformation imaging is a very attractive clinical tool for the assessment of right ventricular (RV) systolic performance, providing incremental diagnostic and prognostic information over the traditional indices of RV function. Among various imaging modalities, echocardiography is currently the Diffuse midline glioma, H3 K27-altered (DMG) is a fatal tumour that arises in the midline structures of the brain. When located in the pons, it is more commonly referred to as diffuse intrinsic pontine glioma (DIPG). DMG/DIPG is usually diagnosed when children are < 10 years, and it has a median overall survival of < 12 months after diagnosis. Radiological imaging is still the gold standard for DIPG diagnosis while the use of biopsy procedures led to our knowledge on its biology, such as with the identification of the canonical histone H3K27M mutation. However, the need to improve survival encourages the development of non-invasive, fast and inexpensive assays on biofluids for optimizing molecular diagnoses in DMG/DIPG. Here, we propose a rapid, new, imaging and epigenetics-based approach to diagnose DMG/DIPG in the plasma of paediatric patients.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30300 - Health sciences

Project
<a href="/en/project/NU23-03-00318" target="_blank" >NU23-03-00318: Free circulating histone complexes as diagnostic tool for central nervous system (CNS) pediatric cancers.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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