Response to Letter to Editor by A. Derbalah et al.: the role of automation in enhancing reproducibility and interoperability of PBPK models

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082277" target="_blank" >RIV/00159816:_____/25:00082277 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14310/25:00143556

Result on the web

<a href="https://academic.oup.com/bib/article/26/1/bbaf060/8006249" target="_blank" >https://academic.oup.com/bib/article/26/1/bbaf060/8006249</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/bib/bbaf060" target="_blank" >10.1093/bib/bbaf060</a>

Result language

angličtina

Original language name

Response to Letter to Editor by A. Derbalah et al.: the role of automation in enhancing reproducibility and interoperability of PBPK models

Original language description

This correspondence highlights the role of automation in physiologically based pharmacokinetic (PBPK) modeling, particularly for complex biologics models. It references the approaches of Sepp et al. (2019) and Liu et al. (2024), who implemented automated code generation using MATLAB and the Ubiquity R-package, respectively, to manage multi-compartment tissue models including vascular, endothelial, endosomal, and interstitial sub-compartments. Automation improves model accessibility, reproducibility, and error reduction, especially for large-scale models, while manual scripting remains valuable for smaller models, teaching, and understanding model mechanics. The authors emphasize the potential of open collaborative initiatives, such as ELIXIR, to advance standardization and community-driven development of automated PBPK modeling workflows.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10609 - Biochemical research methods

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Briefings in Bioinformatics

ISSN

1467-5463

e-ISSN

1477-4054

Volume of the periodical

26

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

2

Pages from-to

nestránkováno

UT code for WoS article

001417203500001

EID of the result in the Scopus database

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