ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082387" target="_blank" >RIV/00159816:_____/25:00082387 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00143288
Result on the web
<a href="https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1563969/full" target="_blank" >https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1563969/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fonc.2025.1563969" target="_blank" >10.3389/fonc.2025.1563969</a>

Result language
angličtina
Original language name
ERK3/MAPK6 promotes triple-negative breast cancer progression through collective migration and EMT plasticity
Original language description
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, in which epithelial-to-mesenchymal transition (EMT) plasticity is required for successful metastasis. ERK3 has been implicated in promoting breast cancer migration and invasion, but the mechanisms remain elusive. Here, we investigated ERK3 expression across patient-derived datasets and explored its role in promoting EMT plasticity using different 2D and 3D in vitro models to investigate cell-extracellular matrix adhesion, migration and invasion, anchorage-independent growth, extravasation and colonization. We have established an association between ERK3 overexpression and aggressive breast cancer phenotypes, higher tumour plasticity, as informed by its grade, and poor clinical outcomes. Based on the hypothesis that ERK3 contributes to TNBC progression by supporting a partial-EMT state, we showed that ERK3 contributes to different steps of the metastatic process, especially by enabling collective migration but also by modulating other functional aspects related to an active EMT program. In conclusion, our results demonstrate that ERK3 contributes to TNBC progression and potentially metastasis by promoting EMT plasticity and collective migration.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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