Dementia with Lewy Bodies (DLB), Parkinson's Disease (PD), and Multiple System Atrophy (MSA) Are Synucleopathies Characterized by Increased Serum Levels of Plasminogen Activator Inhibitor-1 (PAI-1)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082461" target="_blank" >RIV/00159816:_____/25:00082461 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/25:10498786 RIV/00064203:_____/25:10498786

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acsomega.4c10959" target="_blank" >https://pubs.acs.org/doi/10.1021/acsomega.4c10959</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsomega.4c10959" target="_blank" >10.1021/acsomega.4c10959</a>

Result language

angličtina

Original language name

Dementia with Lewy Bodies (DLB), Parkinson's Disease (PD), and Multiple System Atrophy (MSA) Are Synucleopathies Characterized by Increased Serum Levels of Plasminogen Activator Inhibitor-1 (PAI-1)

Original language description

Dementia with Lewy bodies (DLB), Parkinson&apos;s disease (PD), and multiple system atrophy (MSA) are neurodegenerative disorders characterized by abnormal accumulation of alpha-synuclein. Plasmin is a serine protease with a role in various physiological processes, including tissue and synaptic remodeling, inflammation regulation, and modulation of neurotrophic factors. It has also been shown that plasmin is able to cleave extracellular alpha-synuclein in neuronal cell cultures. The plasminogen activator inhibitor-1 (PAI-1) and the tissue plasminogen activator (tPA) regulate the synthesis and activity of plasmin in the brain. We measured the serum levels of tPA and PAI-1 in 30 DLB, 10 PD, and 12 MSA patients and compared them to 10 adults (controls). tPA and PAI-1 serum protein concentrations were quantified by ELISA and compared across the groups. The findings demonstrated that PAI-1 serum levels were increased in DLB (p &lt; 0.05), PD (p &lt; 0.01), and MSA (p &lt; 0.001) patients as compared to controls. In addition, MSA patients had higher PAI-1 serum levels (p &lt; 0.01) as compared to DLB patients, showing the highest PAI-1 levels among all groups. No differences in tPA serum levels were found among groups. Our findings suggest an involvement of plasmin system in these synucleinopathies although there are some limitations due to the heterogeneity of our cohort of participants. Thus, these data must be seen as preliminary observations and further studies in larger and more homogenous cohorts are needed before drawing definitive conclusions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS OMEGA

ISSN

2470-1343

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

23

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

24194-24199

UT code for WoS article

001503723600001

EID of the result in the Scopus database

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