Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082525" target="_blank" >RIV/00159816:_____/25:00082525 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/25:10498926 RIV/00064203:_____/25:10498926

Result on the web

<a href="https://www.nature.com/articles/s41588-025-02227-w" target="_blank" >https://www.nature.com/articles/s41588-025-02227-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41588-025-02227-w" target="_blank" >10.1038/s41588-025-02227-w</a>

Result language

angličtina

Original language name

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

Original language description

A polygenic score (PGS) for Alzheimer&apos;s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30101 - Human genetics

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nature Genetics

ISSN

1061-4036

e-ISSN

1546-1718

Volume of the periodical

57

Issue of the periodical within the volume

7

Country of publishing house

DE - GERMANY

Number of pages

24

Pages from-to

nestránkováno

UT code for WoS article

001511340900001

EID of the result in the Scopus database

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