The Role of Sonication in Improving the Detection of Periprosthetic Joint Infections: a Prospective Analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F25%3A00082547" target="_blank" >RIV/00159816:_____/25:00082547 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/25:00143945
Result on the web
<a href="https://achot.cz/artkey/ach-202504-0001_the-role-of-sonication-in-improving-the-detection-of-periprosthetic-joint-infections-a-prospective-analysis.php" target="_blank" >https://achot.cz/artkey/ach-202504-0001_the-role-of-sonication-in-improving-the-detection-of-periprosthetic-joint-infections-a-prospective-analysis.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.55095/achot2024/061" target="_blank" >10.55095/achot2024/061</a>
Alternative languages
Result language
angličtina
Original language name
The Role of Sonication in Improving the Detection of Periprosthetic Joint Infections: a Prospective Analysis
Original language description
Purpose of the study The diagnosis of periprosthetic joint infection (PJI) can be particularly challenging in cases of low-grade chronic infection. The suspicion of infection is typically confirmed through cultures of synovial fluid and periprosthetic tissue. However, these methods may not always detect low-grade infections, which can lead to persistent infection and early failure of the prosthesis. The purpose of this study was to evaluate the effectiveness of sonication in enhancing the detection of PJI using polymerase chain reaction (PCR) analysis. Material and methods A prospective cohort of 26 patients, suspected of having mitigated PJI, underwent surgery at the First Department of Orthopaedic Surgery, St. Anne's University Hospital in Brno between 2019 and 2024. The cohort included 16 women and 10 men, aged 56 to 82 years, with infections involving hip (11 cases) or knee prostheses (15 cases). Standard PCR and sonication followed by PCR were used to confirm PJI. Results In 20 out of 26 cases, both standard PCR and sonication-assisted PCR detected the infection(p= 0.014). However, in 6 cases, standard PCR failed to identify the pathogen, whereas sonication followed by PCR confirmed the infection. Among these, 4 cases had significantly positive results, and 2 showed weak positivity. The most common pathogens detected were coagulase-negative Staphylococcus (12 cases), followed by Staphylococcus aureus, Pseudomonas aeruginosa, and others. Conclusions The findings of this study indicate that the integration of sonication with PCR markedly enhances the detection of PJI, especially in instances where standard PCR techniques may be insufficient, such as in low-grade chronic infections. (C) 2025, Galen s.r.o.. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30211 - Orthopaedics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Acta chirurgiae orthopaedicae et traumatologiae Čechoslovaca
ISSN
0001-5415
e-ISSN
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Volume of the periodical
92
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
187-194
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-105014996473