Development and Imaging of an Anthropomorphic Phantom for Molecular Radiotherapy Dosimetry Multicenter Intercomparison Exercises
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00177016%3A_____%2F23%3AN0000065" target="_blank" >RIV/00177016:_____/23:N0000065 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.ejmp.2023.102583" target="_blank" >https://doi.org/10.1016/j.ejmp.2023.102583</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmp.2023.102583" target="_blank" >10.1016/j.ejmp.2023.102583</a>
Alternative languages
Result language
angličtina
Original language name
Development and Imaging of an Anthropomorphic Phantom for Molecular Radiotherapy Dosimetry Multicenter Intercomparison Exercises
Original language description
Příspěvek ČMI: příprava standardizovaného radioaktivního roztoku, účast na zpracování dat Validation of a Molecular Radiotherapy (MRT) dosimetry system requires imaging data for which an accompanying "ground truth" pharmacokinetic model and absorbed dose calculation are known. The use of anthropomorphic 3D printed phantoms, corresponding to the organs at risk for a specific therapy, are a promising avenue to provide this imaging data. We present methodology for the design, production and filling of a phantom for validation of 177Lu dotate dosimetry calculations. A pharmacokinetic model is presented with activity concentrations corresponding to common imaging timepoints. Results for the accuracy of phantom filling reproduce the activity concentrations from the pharmacokinetic model for all timepoints and organs within measurement uncertainties, with a mean deviation of 0.6(8)%. The imaging dataset, ancillary data and phantoms designs are provided as a source of well characterized input data for the validation of clinical MRT dosimetry systems.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
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OECD FORD branch
10304 - Nuclear physics
Result continuities
Project
<a href="/en/project/8B16002" target="_blank" >8B16002: Metrology for clinical implementation of dosimetry in molecular radiotherapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physica Medica
ISSN
1120-1797
e-ISSN
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Volume of the periodical
109
Issue of the periodical within the volume
102583
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
11
Pages from-to
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UT code for WoS article
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EID of the result in the Scopus database
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