Paraganglioma-like medullary thyroid carcinoma: fine needle aspiration cytology features with histological correlation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F09%3A00201709" target="_blank" >RIV/00179906:_____/09:00201709 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/09:00208713 RIV/00023761:_____/09:#0000367

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Paraganglioma-like medullary thyroid carcinoma: fine needle aspiration cytology features with histological correlation

Original language description

Two cases of an extremely rare paraganglioma-like variant of medullary thyroid carcinoma(MTC) are reported.The cytological smears contained predominantly ovoid to spindled epithelial cells arranged in cohesive three-dimensional clusters with sharp margins; isolated individual cells were rare.No colloid or amyloid was present in the background. Tumour cells showed significant nuclear atypia with occasional bizarre and binucleated cells. Their chromatin was coarse, granular, sometimes with grooves and intranuclear inclusions. Calcitonin was demonstrated in case 2. Histology confirmed paraganglioma variant of MTC in both cases. Mutation of RET proto-oncogene in exon 16 (Met918Thr) - germline in case 2 and somatic in case 1 was detected by DNA sequencing in both cases.This is the first report of cytological findings in the paraganglioma-like variant of MTC. Despite its rarity, it can be reliably diagnosed by FNAC.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

—

Project

<a href="/en/project/NR9165" target="_blank" >NR9165: Main genetic causes and their modifiers in the pathogenesis of thyroid cancer</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cytopathology

ISSN

0956-5507

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

4

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

—

UT code for WoS article

000266015500007

EID of the result in the Scopus database

—