Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F10%3A10084225" target="_blank" >RIV/00179906:_____/10:10084225 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17310/10:A1100Z1N RIV/00843989:_____/10:00101357

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Long-term protection against hepatitis B after newborn vaccination: 20-year follow-up

Original language description

Objectives: Hepatitis B vaccination in children born to hepatitis B surface antigen positive mothers considerably decreased risk of the vertical transmission. Methods: Combine passive-active immunisation was used in 665 newborns of HBsAg positive mothersin the period 1988-2006 years. Results: Protective anti-HBs level after immunisation was proved in 574 of 620 children (93 %). Persistence of protective anti-HBs antibodies was detected in 70 %, 40 % and 25 % children in 5, 10 and 15 years of life. Vertical transmission with chronic HBsAg carrier status was detected in 2 infants. Anti-HBc seroconversion was proven in 10 children from 3 to 15 years of age. Natural boosting with an anti-HBs increase was detected in 38 children. Conclusions: Combined active-passive immunisation of newborns against hepatitis B provides persistent protection up to adolescence despite frequent waning anti-HBs antibodies.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FN - Epidemiology, infection diseases and clinical immunology

OECD FORD branch

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Project

<a href="/en/project/NR9275" target="_blank" >NR9275: Vaccination against hepatitis B in newborns of HBsAg positive mothers - long-term evaluation of protection</a><br>

Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Infection

ISSN

0300-8126

e-ISSN

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Volume of the periodical

38

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

6

Pages from-to

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UT code for WoS article

000282222200008

EID of the result in the Scopus database

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