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Testing of cryopreserved concentrates at infusion leads to standardization of engraftment in autologous peripheral blood progenitor cell transplantation

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10132548" target="_blank" >RIV/00179906:_____/11:10132548 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Testing of cryopreserved concentrates at infusion leads to standardization of engraftment in autologous peripheral blood progenitor cell transplantation

  • Original language description

    The aim of the study performed at 29 patients undergoing autologous peripheral blood progenitor cell (PBPC) transplantation was to obtain data on total number of thawed infused nucleated cells and on their viability as well as on the number of infused CD34+ cells and CFU-GM. To prevent delayed engraftment (more than 21 days) the minimum cell dose per kg of patient's weight was adjusted to 2x10exp6 CD34+ and 2x10exp5 CFU-GM. As the PBPC concentrates were cryopreserved in presence of 10% dimethylsulphoxide (DMSO) the consequences of this approach on the total infused volume were evaluated. Engraftment within 21 days was achieved in 97 % of patients. The effort to control the risk of delayed engraftment led, however, to the need to accept higher risk of DMSO toxicity.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    23rd IIR International Congress of Refrigeration

  • ISBN

    978-2-913149-88-5

  • ISSN

    1025-9031

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    3609-3612

  • Publisher name

    International Institute of Refrigeration

  • Place of publication

    Praha

  • Event location

    Prague, Czech Republic

  • Event date

    Aug 21, 2011

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article

    000310485802003