Testing of cryopreserved concentrates at infusion leads to standardization of engraftment in autologous peripheral blood progenitor cell transplantation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F11%3A10132548" target="_blank" >RIV/00179906:_____/11:10132548 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Testing of cryopreserved concentrates at infusion leads to standardization of engraftment in autologous peripheral blood progenitor cell transplantation
Original language description
The aim of the study performed at 29 patients undergoing autologous peripheral blood progenitor cell (PBPC) transplantation was to obtain data on total number of thawed infused nucleated cells and on their viability as well as on the number of infused CD34+ cells and CFU-GM. To prevent delayed engraftment (more than 21 days) the minimum cell dose per kg of patient's weight was adjusted to 2x10exp6 CD34+ and 2x10exp5 CFU-GM. As the PBPC concentrates were cryopreserved in presence of 10% dimethylsulphoxide (DMSO) the consequences of this approach on the total infused volume were evaluated. Engraftment within 21 days was achieved in 97 % of patients. The effort to control the risk of delayed engraftment led, however, to the need to accept higher risk of DMSO toxicity.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
23rd IIR International Congress of Refrigeration
ISBN
978-2-913149-88-5
ISSN
1025-9031
e-ISSN
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Number of pages
4
Pages from-to
3609-3612
Publisher name
International Institute of Refrigeration
Place of publication
Praha
Event location
Prague, Czech Republic
Event date
Aug 21, 2011
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000310485802003