Beneficial Effect of Plasma Exchange in the Treatment of Toxic Epidermal Necrolysis: A series of Four Cases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10123476" target="_blank" >RIV/00179906:_____/12:10123476 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/12:10123476

Result on the web

<a href="http://onlinelibrary.wiley.com/doi/10.1002/jca.21213/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/jca.21213/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jca.21213" target="_blank" >10.1002/jca.21213</a>

Result language

angličtina

Original language name

Beneficial Effect of Plasma Exchange in the Treatment of Toxic Epidermal Necrolysis: A series of Four Cases

Original language description

Toxic epidermal necrolysis (TEN) is a rare, life-threatening disease with a high mortality rate that is linked to drug toxicity. There is a lack of data about the underlying pathophysiologic mechanisms and treatment options. The only widely accepted treatment of TEN is withdrawal of the offending drug followed by supportive care. The potential roles of corticosteroids, intravenous immunoglobulin (IVIG) and plasmapheresis (TPE) remain controversial. Aims: We present four patients with severe TEN (all with &gt;80% involvement of body surface) who were treated with TPE following unsuccessful treatment with corticosteroids/IVIG. Methods: TPE was performed using a COBE Spectra blood cell separator. ACD-A was used as anticoagulant fluid and the target-washed plasma volume was one body volume. Plasma was replaced by a 5% solution of human albumin + Ringer&apos;s lactate. Results: The mean number of TPE sessions was 5.25 +- 2.22 (range 3-8). Drugs were implicated as an etiologic agent in each case. TPE led to prompt improvement of acute condition and general health as well as halting of disease progression. Additionally, the restoration of the epithelium began in all four patients. Conclusion: Plasmapheresis should be considered as an alternative treatment modality for patients with the most severe form of TEN if initial treatment with other agents, including corticosteroids and/or IVIG, fails. Drugs were suspected to be the cause of TEN in all four cases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30205 - Hematology

Project

<a href="/en/project/NT12287" target="_blank" >NT12287: The role of insulin resistance in the pathogenesis of cardiometabolic risk in diabetes mellitus</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Apheresis

ISSN

0733-2459

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

215-220

UT code for WoS article

000307100700008

EID of the result in the Scopus database

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