Irradiated stem cells and ageing of the haematopoietic system

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F12%3A10124870" target="_blank" >RIV/00179906:_____/12:10124870 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/12:00390349 RIV/60162694:G44__/12:43874674 RIV/00216208:11150/12:10124870
Result on the web
<a href="http://link.springer.com/article/10.1007%2Fs00411-012-0401-5" target="_blank" >http://link.springer.com/article/10.1007%2Fs00411-012-0401-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00411-012-0401-5" target="_blank" >10.1007/s00411-012-0401-5</a>

Result language
angličtina
Original language name
Irradiated stem cells and ageing of the haematopoietic system
Original language description
In the work presented here, changes in haematopoiesis of mice (B6129SF2/J) were studied 1 year after their whole-body exposure to a dose of 7 Gy (72% of mice survived). The irradiated mice were compared with non-irradiated younger (4 months of age) and older (16 months of age) mice. There was a significant increase in the relative abundance of primitive stem cells with long-term capability of the haematopoiesis recovery lin(-)/Sca-1(+)/CD117(+)/CD34(-) in the bone marrow of mice aged 16 months (irradiated and non-irradiated) compared with those aged 4 months. In terms of the ability to respond to further whole-body irradiation at a dose of 1 Gy, the presence of gamma H2A.X foci was studied in lin(-) bone marrow cells. There was a considerable number ofpersisting foci in lin(-) stem cells isolated from the bone marrow of the older irradiated mice. In the blood count from the peripheral blood of the older mice (both non-irradiated and irradiated at 7 Gy), there was a significant increas
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/OVUOFVZ200806" target="_blank" >OVUOFVZ200806: Noninvasive measurement of proinflamatory markers of oxidative stress in irradiated as an indicator of received dose of radiation. Protective role of acetyl-L-carnitine</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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