Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10124202" target="_blank" >RIV/00179906:_____/13:10124202 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/13:10124202
Result on the web
<a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1468-3083.2012.04643.x/pdf" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/j.1468-3083.2012.04643.x/pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1468-3083.2012.04643.x" target="_blank" >10.1111/j.1468-3083.2012.04643.x</a>
Alternative languages
Result language
angličtina
Original language name
Assessment of methotrexate hepatotoxicity in psoriasis patients: a prospective evaluation of four serum fibrosis markers
Original language description
Low-dose oral methotrexate (MTX) is an effective immunosuppressive therapy for chronic plaque psoriasis. However, its use is hampered by the risk of liver fibrosis. The study compared the results of serial measurements of serum fibrosis markers during the remission-induction phase of treatment with MTX to those of patients on biologic therapy and long-term MTX therapy (> 2 years). Serum concentrations of hyaluronic acid (HA), N-terminal propeptide of collagen type III (PIIINP) and the results of two multi-test algorithms Fibrotest and Hepascore were evaluated in patients with chronic plaque psoriasis (N=24, age: 28-79 years, baseline psoriasis area and severity index PASI 13.5, range 2.2-33) at baseline and weeks 16 and 26 after the start of pharmacokinetically-guided therapy with MTX (Group A). Patients on established therapy with biologics (N=15, Group B) and long-term MTX users (N=10, Group C) with the mean baseline PASI scores of 0.9 and 1.2 were studied in parallel cohorts. At bas
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS10364" target="_blank" >NS10364: Noninvasive monitoring of hepatotoxicity in the course of pharmacokinetically-guided dosing of oral methotrexate and folic acid to psoriasis patients: A two-year prospective study.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the European Academy of Dermatology and Venereology
ISSN
0926-9959
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
8
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
1007-1014
UT code for WoS article
000321893600011
EID of the result in the Scopus database
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