Methylation in the p53 promoter in epithelial ovarian cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10126505" target="_blank" >RIV/00179906:_____/13:10126505 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/13:10126505

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs12094-012-0894-z" target="_blank" >http://link.springer.com/article/10.1007%2Fs12094-012-0894-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12094-012-0894-z" target="_blank" >10.1007/s12094-012-0894-z</a>

Result language

angličtina

Original language name

Methylation in the p53 promoter in epithelial ovarian cancer

Original language description

Ovarian cancer is a leading cause of death from gynecologic tumors, however epigenetic events underlying this transformation are poorly understood. Promoter methylation status of tumor suppressor genes may be associated with transcriptional silencing andtumor progression. It has been shown that methylation located in the promoter region of p53 is associated with low expression of this gene. The aim of this study was to investigate promoter methylation of p53 gene in ovarian cancer by comparison with normal ovarian tissue. We used methylation-specific PCR to compare the methylation status of p53 promoter of 66 tissue samples of ovarian cancer with 37 control samples. In our study methylation specific PCR revealed p53 promoter methylation in 34 of 66 (51.5 %) of specimens with ovarian cancer. These results indicate that methylation in p53 promoter region may play an important role in carcinogenesis of ovarian cancer.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical and Translational Oncology

ISSN

1699-048X

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

2

Country of publishing house

ES - SPAIN

Number of pages

4

Pages from-to

160-163

UT code for WoS article

000314280500011

EID of the result in the Scopus database

—