Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10138954" target="_blank" >RIV/00179906:_____/13:10138954 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/13:10138954
Result on the web
<a href="http://www.nature.com/ng/journal/v45/n9/full/ng.2716.html" target="_blank" >http://www.nature.com/ng/journal/v45/n9/full/ng.2716.html</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/ng.2716" target="_blank" >10.1038/ng.2716</a>
Alternative languages
Result language
angličtina
Original language name
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension
Original language description
A substantial proportion of APAs resembling adrenal zona glomerulosa cells harbor gain-of-function mutations in genes important for the regulation of Na+ and Ca2+, ATP1A1 and CACNA1D, respectively. Mutations in both genes appear to be more common in cohorts enriched for smaller, zona glomerulosa-like APAs, highlight-ing the notion that diagnosis should not rely on finding a definite nodule upon adrenal imaging.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Genetics
ISSN
1061-4036
e-ISSN
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Volume of the periodical
45
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
1055-1060
UT code for WoS article
000323748200016
EID of the result in the Scopus database
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