Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic anthracycline cardiotoxicity in rabbits

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10139301" target="_blank" >RIV/00179906:_____/13:10139301 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/13:10139301 RIV/00216208:11150/13:10139301
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0300483X13001674" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0300483X13001674</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tox.2013.06.012" target="_blank" >10.1016/j.tox.2013.06.012</a>

Result language
angličtina
Original language name
Early and delayed cardioprotective intervention with dexrazoxane each show different potential for prevention of chronic anthracycline cardiotoxicity in rabbits
Original language description
The aim of this study was to compare early and currently recommended delayed intervention with dexrazoxane (DEX) against chronic anthracycline (ANT) cardiotoxicity on the rabbit model - i.e. administration of DEX with each ANT dose or since cumulative dose 300 mg/m2 of ANT, respectively, and to investigate molecular mechanisms involved in this matter. We found that both DEX dosing schedules prevented ANT-induced premature deaths and severe congestive heart failure, but only the early intervention completely prevented the left ventricular dysfunction, myocardial morphological changes, mitochondrial damage and ANT-induced down-regulation of expression of mitochondrial proteins encoded by both nuclear and mitochondrial genome. Further molecular analyses did not support the assumption that DEX cardioprotection is based and directly proportional to protection from ANT-induced oxidative damage and/or deletions in mtDNA. Hence, the present functional, morphological as well as the molecular da
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GA13-15008S" target="_blank" >GA13-15008S: New potential cardioprotective agents: study of structure-activity relationships in various types of myocardial injury</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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