A Resurrection of 7-MEOTA: A Comparison with Tacrine

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10139641" target="_blank" >RIV/00179906:_____/13:10139641 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/13:00397542 RIV/60162694:G44__/13:43874805 RIV/00216208:11160/13:10139641
Result on the web
<a href="http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=24093535.ui" target="_blank" >http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=24093535.ui</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
A Resurrection of 7-MEOTA: A Comparison with Tacrine
Original language description
Alzheimer's disease (AD) is a progressive neurodegenerative dementia which currently represents one of the biggest threats for the human kind. The cure is still unknown and various hypotheses (cholinergic, amyloidal, oxidative, vascular etc.) are investigated in order to understand the pathophysiology of the disease and on this basis find an effective treatment. Tacrine, the first approved drug for the AD disease treatment, has been reported to be a multitargeted drug, however it was withdrawn from themarket particularly due to its hepatotoxicity. Its derivative 7-methoxytacrine (7-MEOTA) probably due to the different metabolization does not exert this side effect. The aim of our study was to compare these two cholinesterase inhibitors from various, mainly cholinergic, points of view relevant for a potential AD drug. We found that 7-MEOTA does not fall behind its more well-known parent compound - tacrine. Furthermore, we found, that 7-MEOTA exerts better properties in most of the test
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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