A method to identify new molecular markers for assessing minimal residual disease in acute leukemia patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10140043" target="_blank" >RIV/00179906:_____/13:10140043 - isvavai.cz</a>
Alternative codes found
RIV/28205227:_____/13:#0000002 RIV/00216208:11120/13:43907564 RIV/00064173:_____/13:#0000326 RIV/00669806:_____/13:10140043
Result on the web
<a href="http://ac.els-cdn.com/S0145212613001951/1-s2.0-S0145212613001951-main.pdf?_tid=c4ceda60-a2a4-11e3-b071-00000aab0f01&acdnat=1393831611_c699c8ed4f9c923bc5c17ac2c5018ce3" target="_blank" >http://ac.els-cdn.com/S0145212613001951/1-s2.0-S0145212613001951-main.pdf?_tid=c4ceda60-a2a4-11e3-b071-00000aab0f01&acdnat=1393831611_c699c8ed4f9c923bc5c17ac2c5018ce3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.leukres.2013.06.009" target="_blank" >10.1016/j.leukres.2013.06.009</a>
Alternative languages
Result language
angličtina
Original language name
A method to identify new molecular markers for assessing minimal residual disease in acute leukemia patients
Original language description
Acute leukemias (AL) comprise a heterogeneous group of hematologic malignancies, and individual patient responses to treatment can be difficult to predict. Monitoring of minimal residual disease (MRD) is thus very important and holds great potential forimproving treatment strategies. Common MRD targets include recurrent cytogenetic abnormalities and mutations in important hematological genes; unfortunately well-characterized targets are lacking in many AL patients. Here we demonstrate a technical approach for the identification and mapping of novel clone-specific chromosomal abnormalities down to the nucleotide level. We used molecular cytogenetics, chromosome microdissection, amplification of the microdissected material, and next-generation sequencing to develop PCR-based MRD assays based on unique breakpoint sequences
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia Research
ISSN
0145-2126
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
10
Country of publishing house
GB - UNITED KINGDOM
Number of pages
11
Pages from-to
1363-1373
UT code for WoS article
000324099100031
EID of the result in the Scopus database
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