Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10140162" target="_blank" >RIV/00179906:_____/13:10140162 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/13:00399482 RIV/00159816:_____/13:00060571 RIV/00216208:11160/13:10140162 RIV/00216224:14310/13:00081911
Result on the web
<a href="http://dx.doi.org/10.4149/gpb_2013031" target="_blank" >http://dx.doi.org/10.4149/gpb_2013031</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/gpb_2013031" target="_blank" >10.4149/gpb_2013031</a>
Alternative languages
Result language
angličtina
Original language name
Epilobium angustifolium extract demonstrates multiple effects on dermal fibroblasts in vitro and skin photo-protection in vivo
Original language description
Stress-induced fibroblast senescence is thought to contribute to skin aging. Ultraviolet light (UV) radiation is the most potent environmental risk factor in these processes. An Epilobium angustifolium (EA) extract was evaluated for its capacity to reverse the senescent response of normal human dermal fibroblasts (NHDF) in vitro and to exhibit skin photo-protection in vivo. The HPLC-UV-MS analysis of the EA preparation identified three major polyphenol groups: tannins (oenothein B), phenolic acids (gallic and chlorogenic acids) and flavonoids. EA extract increased the cell viability of senescent NHDF induced by serum deprivation. It diminished connective tissue growth factor and fibronectin gene expressions in senescent NHDF. Down-regulation of the UV-induced release of both matrix metalloproteinase-1 and -3 and the tissue inhibitor of matrix metalloproteinases-1 and -2, and also down-regulation of the gene expression of hyaluronidase 2 were observed in repeatedly UV-irradiated NHDF af
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
General Physiology and Biophysics
ISSN
0231-5882
e-ISSN
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Volume of the periodical
32
Issue of the periodical within the volume
3
Country of publishing house
SK - SLOVAKIA
Number of pages
13
Pages from-to
347-359
UT code for WoS article
000323629900006
EID of the result in the Scopus database
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