Novel cholinesterase modulators and their ability to interact with DNA

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F13%3A10159488" target="_blank" >RIV/00179906:_____/13:10159488 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/13:50001353
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1386142513006124" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1386142513006124</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.saa.2013.06.008" target="_blank" >10.1016/j.saa.2013.06.008</a>

Result language
angličtina
Original language name
Novel cholinesterase modulators and their ability to interact with DNA
Original language description
In the present work, an interaction of four cholinesterase modulators (1-4) with calf thymus DNA was studied via spectroscopic techniques (UV-Vis, fluorescent spectroscopy and circular dichroism). From UV-Vis spectroscopic analysis, the binding constantsfor DNA-pyridinium oximes complexes were calculated (K = 3.5 104 to 1.4 105 M1). All these measurements indicated that the compounds behave as effective DNA-interacting agents. Electrophoretic techniques proved that ligand 2 inhibited topoisomerase I ata concentration 5 lM.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
ISSN
1386-1425
e-ISSN
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Volume of the periodical
115
Issue of the periodical within the volume
November
Country of publishing house
GB - UNITED KINGDOM
Number of pages
6
Pages from-to
364-369
UT code for WoS article
000324152700042
EID of the result in the Scopus database
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