Expression profiles of fetal membrane nicotinamide adenine dinucleotide phosphate oxidases (NOX) 2 and 3 differentiates spontaneous preterm birth and pPROM pathophysiologies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10281089" target="_blank" >RIV/00179906:_____/14:10281089 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/14:10281089

Result on the web

<a href="http://dx.doi.org/10.1016/j.placenta.2013.12.012" target="_blank" >http://dx.doi.org/10.1016/j.placenta.2013.12.012</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.placenta.2013.12.012" target="_blank" >10.1016/j.placenta.2013.12.012</a>

Result language

angličtina

Original language name

Expression profiles of fetal membrane nicotinamide adenine dinucleotide phosphate oxidases (NOX) 2 and 3 differentiates spontaneous preterm birth and pPROM pathophysiologies

Original language description

Introduction: Nicotinamide adenine dinucleotide phosphate oxidases (NOX 1-5) are enzymes that generate cellular reactive oxygen species (ROS) besides mitochondria and might be important ROS sources associated with pregnancy complications, particularly preterm premature rupture of membranes (pPROM), that has been related to ROS. Objective: To characterize NOX enzymes expression in human fetal membranes. Methods: Differential expression and localization of NOX isoforms in human fetal membranes collected from women with uncomplicated pregnancies at term, preterm birth (PTB) or pPROM and in vitro in normal term membranes maintained in an organ explant system stimulated with water-soluble cigarette smoke extract (wsCSE) were documented by real time PCR andimmunohistochemistry. Results: Fetal membranes from term deliveries, PTB and pPROM expressed NOX 2, 3 and 4 mRNAs whereas NOX 1 and 5 were not detected. NOX 2 expression was 2.3-fold higher in PTB than pPROM (p = 0.005) whereas NOX 3 was

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

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Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Placenta

ISSN

0143-4004

e-ISSN

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Volume of the periodical

35

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

188-194

UT code for WoS article

000333495900006

EID of the result in the Scopus database

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