From pyridinium-based to centrally active acetylcholinesterase reactivators
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10281199" target="_blank" >RIV/00179906:_____/14:10281199 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/14:43875116 RIV/62690094:18470/14:50002711 RIV/00216208:11160/14:10281199
Result on the web
<a href="http://www.ingentaconnect.com/content/ben/mrmc/2014/00000014/00000003/art00001" target="_blank" >http://www.ingentaconnect.com/content/ben/mrmc/2014/00000014/00000003/art00001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1389557514666140219103138" target="_blank" >10.2174/1389557514666140219103138</a>
Alternative languages
Result language
angličtina
Original language name
From pyridinium-based to centrally active acetylcholinesterase reactivators
Original language description
Organophosphates are used as pesticides or misused as warfare nerve agents. Exposure to them can be fatal and death is usually caused by respiratory arrest. For almost six decades, pyridinium oximes represent a therapeutic tool used for the management ofpoisoning with organophosphorus (OP) compounds. However, these compounds possess several drawbacks. Firstly, they are inefficient in the restoration of brain acetylcholinesterase (AChE) activity due to a hard blood-brain barrier penetration. Secondly, there is no broad-spectrum AChE reactivator. Lastly, none of the oximes can reactivate "aged" AChE. In this context, uncharged reactivators represent a new hope in a way of increased bioavailability in the central compartment and better therapeutic management of the OP poisoning.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT12062" target="_blank" >NT12062: Preparation and biological evaluation of new therapeutics against to pesticides</a><br>
Continuities
O - Projekt operacniho programu
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mini reviews in medicinal chemistry
ISSN
1389-5575
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
3
Country of publishing house
AE - UNITED ARAB EMIRATES
Number of pages
7
Pages from-to
215-221
UT code for WoS article
000340832800001
EID of the result in the Scopus database
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