6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10282174" target="_blank" >RIV/00179906:_____/14:10282174 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/14:43875182 RIV/00216208:11160/14:10282174 RIV/61989100:27240/14:86090357
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0960894X14010130" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0960894X14010130</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bmcl.2014.09.060" target="_blank" >10.1016/j.bmcl.2014.09.060</a>
Alternative languages
Result language
angličtina
Original language name
6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity
Original language description
Quaternary ammonium salts substituted with a long alkyl chain exemplify a trustworthy group of medicinal compounds frequently employed as antifungal and antibacterial agents. A great asset of these surfactants underlying their widespread use is low localand system toxicity in humans. In this Letter, a series of novel quaternary 6-hydroxyquinolinium salts with varying length of N-alkyl chain (from C-10 to C-18) was synthesized and tested for in vitro activity against pathogenic bacterial and fungal strains. 6-Hydroxyquinolinium salt with C12 alkyl chain seems to be very interesting candidate due to a high antimicrobial efficacy and cytotoxic safety.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
O - Projekt operacniho programu
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioorganic and Medicinal Chemistry Letters
ISSN
0960-894X
e-ISSN
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Volume of the periodical
24
Issue of the periodical within the volume
22
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
5238-5241
UT code for WoS article
000343901400021
EID of the result in the Scopus database
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