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6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10282174" target="_blank" >RIV/00179906:_____/14:10282174 - isvavai.cz</a>

  • Alternative codes found

    RIV/60162694:G44__/14:43875182 RIV/00216208:11160/14:10282174 RIV/61989100:27240/14:86090357

  • Result on the web

    <a href="http://www.sciencedirect.com/science/article/pii/S0960894X14010130" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0960894X14010130</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bmcl.2014.09.060" target="_blank" >10.1016/j.bmcl.2014.09.060</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    6-Hydroxyquinolinium salts differing in the length of alkyl side-chain: Synthesis and antimicrobial activity

  • Original language description

    Quaternary ammonium salts substituted with a long alkyl chain exemplify a trustworthy group of medicinal compounds frequently employed as antifungal and antibacterial agents. A great asset of these surfactants underlying their widespread use is low localand system toxicity in humans. In this Letter, a series of novel quaternary 6-hydroxyquinolinium salts with varying length of N-alkyl chain (from C-10 to C-18) was synthesized and tested for in vitro activity against pathogenic bacterial and fungal strains. 6-Hydroxyquinolinium salt with C12 alkyl chain seems to be very interesting candidate due to a high antimicrobial efficacy and cytotoxic safety.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FR - Pharmacology and apothecary chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    O - Projekt operacniho programu

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Bioorganic and Medicinal Chemistry Letters

  • ISSN

    0960-894X

  • e-ISSN

  • Volume of the periodical

    24

  • Issue of the periodical within the volume

    22

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    4

  • Pages from-to

    5238-5241

  • UT code for WoS article

    000343901400021

  • EID of the result in the Scopus database