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A phase 2 randomized controlled trial of a multicomponent meningococcal serogroup B vaccine (I) Effects of prophylactic paracetamol on immunogenicity and reactogenicity of routine infant vaccines and 4CMenB

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10283196" target="_blank" >RIV/00179906:_____/14:10283196 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11150/14:10283196

  • Result on the web

    <a href="http://dx.doi.org/10.4161/hv.28666" target="_blank" >http://dx.doi.org/10.4161/hv.28666</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.4161/hv.28666" target="_blank" >10.4161/hv.28666</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    A phase 2 randomized controlled trial of a multicomponent meningococcal serogroup B vaccine (I) Effects of prophylactic paracetamol on immunogenicity and reactogenicity of routine infant vaccines and 4CMenB

  • Original language description

    The novel meningococcal serogroup B vaccine (4CMenB, Bexsero (R)), recently approved in Europe and Australia, may soon be included in routine infant immunization schedules, subject to guidance from national or regional recommending bodies. In the development of 4CMenB and consistent with other newly introduced vaccines, clinical studies have shown concomitant administration with routine infant vaccines induces an incremental increase in some reactions, including fever. As this may hinder acceptability,we examined the impact of prophylactic paracetamol on the occurrence of fever and other solicited reactions, as well as the immune responses to study vaccines, in a prospectively designed study. 4CMenB was administered as a 4-dose series at 2, 3, 4, and12 months of age concomitantly with routine infant vaccines: DTaP-HBV-IPV/Hib and PCV7, with or without prophylactic paracetamol; a third group received MenC vaccine. Immune responses to 4CMenB were not decreased by the use of paracetamol

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Human Vaccines and Immunotherapeutics

  • ISSN

    2164-5515

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    1993-2004

  • UT code for WoS article

    000342901200035

  • EID of the result in the Scopus database