New Strategy for the Synthesis of 3,4,5-trisubstituted Isoxazolines from Allyl Compounds

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F14%3A10287516" target="_blank" >RIV/00179906:_____/14:10287516 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/14:10287516 RIV/62157124:16370/14:43872696
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
New Strategy for the Synthesis of 3,4,5-trisubstituted Isoxazolines from Allyl Compounds
Original language description
A new strategy for the synthesis of trans-and cis + trans-3,4,5-trisubstituted isoxazolines from allyl compounds of QCH(2)CH=CH2 type (Q = PhO, 2,2'-bithiophen-5-yl, BuO, Me3CS, PhN(COMe) and others) has been developed. The dipolarophiles are prepared via: a) Ru-carbene catalysed metathesis of Qallyl; b) catalytic isomerization followed by Ru-carbene mediated metathesis; c) Ru-carbene catalysed metathesis followed by isomerization. 1,3-dipolar cycloaddition of nitrile oxide to dipolarophiles obtained via route a), b) or c), including high pressure activated reactions leads to 3,4,5-trisubstituted isoxazolines. Quantitative E-stereoselective homometathesis of some QCH(2)CH=CH2 to (E)-QCH(2)CH=CHCH(2)Q and new highly effective ruthenium and basic catalytic systems for the isomerization of allyl compounds have also been presented. Moreover, easily available (Z)-XCH2CH=CHCH2X allyl compounds were used for the synthesis of cis-3,4,5-trisubstituted isoxazolines. It has been proved by in vitr
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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