Synthesis and anti-infective evaluation of 5-amino-N-phenylpyrazine-2-carboxamides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F15%3A10312217" target="_blank" >RIV/00179906:_____/15:10312217 - isvavai.cz</a>
Result on the web
<a href="http://www.prolekare.cz/linkout/52405" target="_blank" >http://www.prolekare.cz/linkout/52405</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Synthesis and anti-infective evaluation of 5-amino-N-phenylpyrazine-2-carboxamides
Original language description
A series of eleven novel 5-amino-N-phenylpyrazine-2-carboxamides were synthesized and evaluated for in vitro anti-infective properties. Prepared compounds were characterized by IR, 1H NMR and 13C NMR spectra, elementary analysis and melting points. Lipophilicity parameters Log P and ClogP were calculated. None of the compounds was effective against any of tested mycobacterial strains (Mycobacterium tuberculosis H37Rv, M. kansasii, M. avium) up to concentration of 100 mu g/mL. 5-amino-N-(2,5-dimethylphenyl) pyrazine-2-carboxamide (3) exerted moderate antibacterial activity against Staphylococcus aureus (MIC = 62.5 mu M). No antifungal activity was detected. Several compounds exerted moderate antiviral activity against influenza A viruses at the level of tens of mu M.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/NT13346" target="_blank" >NT13346: Design and enzyme targeting of antibacterial active compounds against multidrug resistant strains</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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