Increase of serum interleukin 6 and interferon γ is associated with the number of impulses in patients with supraventricular arrhythmias treated with radiofrequency catheter ablation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10317094" target="_blank" >RIV/00179906:_____/16:10317094 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/16:10317094

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2015.038" target="_blank" >http://dx.doi.org/10.5507/bp.2015.038</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2015.038" target="_blank" >10.5507/bp.2015.038</a>

Result language

angličtina

Original language name

Increase of serum interleukin 6 and interferon γ is associated with the number of impulses in patients with supraventricular arrhythmias treated with radiofrequency catheter ablation

Original language description

BACKGROUND:Activation of the immune system plays a pathogenic role in the process of myocardial remodeling in patients with supraventricular arrhythmias. The intensity of this process is associated with the effectiveness of electrical cardioversion and radiofrequency catheter ablation (RFA). The aim of this study was to test the ability of the biochip microarray to detect immune parameters in patients with supraventricular arrhythmias undergoing RFA treatment. METHODS: We used a biochip-based microarray system to determine multiple immune parameters in a group of 35 patients who had undergone RFA for atrioventricular nodal reentry tachycardia (AVNRT), atrial flutter (AFL) and atrial fibrillation (AF). RESULTS: Before the procedure, serum IL-6 and VEGF levels were significantly increased in patients with atrial fibrillation compared to patients with AVNRT (IL-6: 6.4+-6.3 ng/L vs. 1.5+-0.7 ng/L, P < 0.01; VEGF: 132.4+-74 ng/L vs. 88.5+-56.4 ng/L, P < 0.01). After the procedure, serum IL-6, VEGF, IFN-γ and MCP-1 levels significantly increased compared to baseline (IL-6: 5.2+-4.8 ng/L vs. 2.9+-2.1 ng/L, P < 0.01; VEGF: 195.8+-160 ng/L vs. 119.8+- 110 ng/L, P < 0.05; IFN-γ: 3.1+-1.2 ng/L vs. 2.3+-0.6 ng/L, P < 0.05; MCP-1: 104.1+-84.5 ng/L vs. 54.5+-50 ng/L, P < 0.05). Serum IL-6 and IFN-γ were associated with the number of RFA applications (IL-6: r = 0.56, n 33; IFN-γ: r = 0.47, n 33). CONCLUSIONS: This study showed that biochip-based microarray can be useful in the detection of immune activation in patients with arrhythmias and can detect myocardial injury after RF procedures.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Volume of the periodical

160

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

106-110

UT code for WoS article

000373390800013

EID of the result in the Scopus database

2-s2.0-84962339953