Role of S100 Proteins in Colorectal Carcinogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10323416" target="_blank" >RIV/00179906:_____/16:10323416 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/16:10323416
Result on the web
<a href="http://dx.doi.org/10.1155/2016/2632703" target="_blank" >http://dx.doi.org/10.1155/2016/2632703</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2016/2632703" target="_blank" >10.1155/2016/2632703</a>
Alternative languages
Result language
angličtina
Original language name
Role of S100 Proteins in Colorectal Carcinogenesis
Original language description
The family of S100 proteins represents 25 relatively small (9-13 kD) calcium binding proteins. These proteins possess a broad spectrum of important intracellular and extracellular functions. Colorectal cancer is the third most common cancer in men (after lung and prostate cancer) and the second most frequent cancer in women (after breast cancer) worldwide. S100 proteins are involved in the colorectal carcinogenesis through different mechanisms: they enable proliferation, invasion, and migration of the tumour cells; furthermore, S100 proteins increase angiogenesis and activateNF-kappa beta signaling pathway, which plays a key role in the molecular pathogenesis especially of colitis-associated carcinoma. The expression of S100 proteins in the cancerous tissue and serum levels of S100 proteins might be used as a precise diagnostic and prognostic marker in patients with suspected or already diagnosed colorectal neoplasia. Possibly, in the future, S100 proteins will be a therapeutic target for tailored anticancer therapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NT13413" target="_blank" >NT13413: Determination of apoptosis in the bioptic samples taken from the colon</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gastroenterology Research and Practice
ISSN
1687-6121
e-ISSN
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Volume of the periodical
2016
Issue of the periodical within the volume
November
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000371042600001
EID of the result in the Scopus database
2-s2.0-84961351825