Severe deoxyribonucleic acid damage after out-of-hospital cardiac arrest in successfully resuscitated humans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10323422" target="_blank" >RIV/00179906:_____/16:10323422 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/16:10323422
Result on the web
<a href="http://dx.doi.org/10.1016/j.ijcard.2016.01.046" target="_blank" >http://dx.doi.org/10.1016/j.ijcard.2016.01.046</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ijcard.2016.01.046" target="_blank" >10.1016/j.ijcard.2016.01.046</a>
Alternative languages
Result language
angličtina
Original language name
Severe deoxyribonucleic acid damage after out-of-hospital cardiac arrest in successfully resuscitated humans
Original language description
Out-of-hospital cardiac arrest (OHCA) is a highly stressful event with a transient common ischaemic - reperfusion injury in successfully resuscitated victims. Survival rate of patients resuscitated from OHCA remains too low (10%) [1]. It has been shown that stress induces the most severe form of deoxyribonucleic acid (DNA) damage - double strand breaks (DSBs) [2], [3], [4] and [5]. The reliable marker of DNA DSB damage, respectively its reparation is the phosphorylated histone H2AX (γH2AX), which reaches maximum levels in peripheral blood lymphocytes between 10 and 60 min following cell exposure [3], [4], [5], [6], [7] and [8]. The effect of OHCA on DNA integrity has not been described. Thus the aim of the authors was to describe in patients successfully resuscitated from OHCA the occurrence of DNA DSB damage and evaluate γH2AX short-term prognostic (30-day survival) role.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Cardiology
ISSN
0167-5273
e-ISSN
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Volume of the periodical
207
Issue of the periodical within the volume
March
Country of publishing house
IE - IRELAND
Number of pages
3
Pages from-to
33-35
UT code for WoS article
000371271400010
EID of the result in the Scopus database
2-s2.0-84957936142