Adverse events in apheresis: An update of the WAA registry data

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F16%3A10331717" target="_blank" >RIV/00179906:_____/16:10331717 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/16:10331717 RIV/00843989:_____/16:E0105401

Result on the web

<a href="http://dx.doi.org/10.1016/j.transci.2016.01.003" target="_blank" >http://dx.doi.org/10.1016/j.transci.2016.01.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transci.2016.01.003" target="_blank" >10.1016/j.transci.2016.01.003</a>

Result language

angličtina

Original language name

Adverse events in apheresis: An update of the WAA registry data

Original language description

Apheresis with different procedures and devices are used for a variety of indications that may have different adverse events (AEs). The aim of this study was to clarify the extent and possible reasons of various side effects based on data from a multinational registry. The WAA-apheresis registry data focus on adverse events in a total of 50846 procedures in 7142 patients (42% women). AEs were graded as mild, moderate (need for medication), severe (interruption due to the AE) or death (due to AE). More AEs occurred during the first procedures versus subsequent (8.4 and 5.5%, respectively). AEs were mild in 2.4% (due to access 54%, device 7%, hypotension 15%, tingling 8%), moderate in 3% (tingling 58%, urticaria 15%, hypotension 10%, nausea 3%), and severe in 0.4% of procedures (syncope/hypotension 32%, urticaria 17%, chills/fever 8%, arrhythmia/asystole 4.5%, nausea/vomiting 4%). Hypotension was most common if albumin was used as the replacement fluid, and urticaria when plasma was used. Arrhythmia occurred to similar extents when using plasma or albumin as replacement. In 64% of procedures with bronchospasm, plasma was part of the replacement fluid used. Severe AEs are rare. Although most reactions are mild and moderate, several side effects may be critical for the patient. We present side effects in relation to the procedures and suggest that safety is increased by regular vital sign measurements, cardiac monitoring and by having emergency equipment nearby.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Transfusion and Apheresis Science

ISSN

1473-0502

e-ISSN

—

Volume of the periodical

54

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

2-15

UT code for WoS article

000374614700002

EID of the result in the Scopus database

2-s2.0-84954304755