HPLC determination of K027 in the body of pregnant mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F17%3A10337881" target="_blank" >RIV/00179906:_____/17:10337881 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1556/1326.2017.29.1.06" target="_blank" >http://dx.doi.org/10.1556/1326.2017.29.1.06</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1556/1326.2017.29.1.06" target="_blank" >10.1556/1326.2017.29.1.06</a>

Result language
angličtina
Original language name
HPLC determination of K027 in the body of pregnant mice
Original language description
Distribution of K027, a hydrophilic, positively charged compound is monitored in the body of pregnant mice using high-performance liquid chromatography (HPLC). Intraperitoneal injection was done on the 18th day of pregnancy; the plasma and brains of the mother mice, placentae and the fetuses' brains were dissected following 5, 15, 30, 60, and 120 min of treatment. Significant incorporation of K027 was found in the placentae and in fetuses' brains relative to its levels in the mothers' plasma and brains. This incorporation warns of a possible adjustment of dose of pyridinium aldoxime antidotes in case of pregnancy. Further studies with different gestational periods and animal models are warranted.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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