Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F18%3A10380493" target="_blank" >RIV/00179906:_____/18:10380493 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1002/jat.3622" target="_blank" >http://dx.doi.org/10.1002/jat.3622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jat.3622" target="_blank" >10.1002/jat.3622</a>

Result language

angličtina

Original language name

Multifunctional properties of novel tacrine congeners: cholinesterase inhibition and cytotoxic activity

Original language description

This review describes the synthesis of a wide range of novel tetrahydroacridine derivatives (tiocyanates, selenocyanates, ureas, selenoureas, thioureas, isothioureas, disulfides, diselenides and several tacrine homo- and hetro-hybrids). These tacrine congeners exhibit significant anticholinesterase and cytotoxic properties and may therefore be of considerable potential for the development of new drugs for the treatment of Alzheimer&apos;s disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Toxicology

ISSN

0260-437X

e-ISSN

—

Volume of the periodical

38

Issue of the periodical within the volume

11

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1377-1387

UT code for WoS article

000445615200001

EID of the result in the Scopus database

2-s2.0-85044943644