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Highly toxic ribosome-inactivating proteins as chemical warfare or terrorist agents

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F18%3A10383508" target="_blank" >RIV/00179906:_____/18:10383508 - isvavai.cz</a>

  • Result on the web

    <a href="https://mmsl.cz/pdfs/mms/2018/04/03.pdf" target="_blank" >https://mmsl.cz/pdfs/mms/2018/04/03.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.31482/mmsl.2018.027" target="_blank" >10.31482/mmsl.2018.027</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Highly toxic ribosome-inactivating proteins as chemical warfare or terrorist agents

  • Original language description

    Biological weapons include infectious agents and toxins. Toxins are poisons produced by living organisms. An important group of toxins are ribosome inactivating proteins (RIPs) of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. RIPs have been of great scientific interest due to their importance in human health, as both pathogenic agents and therapeutics, but also due to their potential use in biological warfare and bioterrorism. RIPs relevant to bioterrorism include mainly ricin and abrin. Ricin is protein produced in the seeds of the castor oil plant (Ricinus communis). Abrin is protein that has been isolated from the seeds of Abrus precatorius. Both inactivate ribosomes, which results in toxicity because of the inhibition of protein synthesis. Abrin and ricin are substances very toxic to humans in all types of administration, with the exception of oral administration. Symptoms include nausea, diarrhea, tachycardia, hypotension, and seizures. Treatment is supportive, and no antidote exists.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>ost</sub> - Miscellaneous article in a specialist periodical

  • CEP classification

  • OECD FORD branch

    30108 - Toxicology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Vojenské zdravotnické listy

  • ISSN

    0372-7025

  • e-ISSN

  • Volume of the periodical

    87

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    11

  • Pages from-to

    158-168

  • UT code for WoS article

  • EID of the result in the Scopus database