Highly toxic ribosome-inactivating proteins as chemical warfare or terrorist agents

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F18%3A10383508" target="_blank" >RIV/00179906:_____/18:10383508 - isvavai.cz</a>
Result on the web
<a href="https://mmsl.cz/pdfs/mms/2018/04/03.pdf" target="_blank" >https://mmsl.cz/pdfs/mms/2018/04/03.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.31482/mmsl.2018.027" target="_blank" >10.31482/mmsl.2018.027</a>

Result language
angličtina
Original language name
Highly toxic ribosome-inactivating proteins as chemical warfare or terrorist agents
Original language description
Biological weapons include infectious agents and toxins. Toxins are poisons produced by living organisms. An important group of toxins are ribosome inactivating proteins (RIPs) of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. RIPs have been of great scientific interest due to their importance in human health, as both pathogenic agents and therapeutics, but also due to their potential use in biological warfare and bioterrorism. RIPs relevant to bioterrorism include mainly ricin and abrin. Ricin is protein produced in the seeds of the castor oil plant (Ricinus communis). Abrin is protein that has been isolated from the seeds of Abrus precatorius. Both inactivate ribosomes, which results in toxicity because of the inhibition of protein synthesis. Abrin and ricin are substances very toxic to humans in all types of administration, with the exception of oral administration. Symptoms include nausea, diarrhea, tachycardia, hypotension, and seizures. Treatment is supportive, and no antidote exists.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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