Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, multi-centre, prospective audit

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F18%3A10387954" target="_blank" >RIV/00179906:_____/18:10387954 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/18:10387954 RIV/00064203:_____/18:10387954 RIV/00216208:11150/18:10387954

Result on the web

<a href="https://doi.org/10.1111/codi.14362" target="_blank" >https://doi.org/10.1111/codi.14362</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/codi.14362" target="_blank" >10.1111/codi.14362</a>

Result language

angličtina

Original language name

Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, multi-centre, prospective audit

Original language description

Introduction: The optimal bowel preparation strategy to minimise the risk of anastomotic leak is yet to be determined. This study aimed to determine whether oral antibiotics combined with mechanical bowel preparation (MBP+Abx) was associated with a reduced risk of anastomotic leak when compared to mechanical bowel preparation alone (MBP) or no bowel preparation (NBP). Methods: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 Left Sided Colorectal Resection audit was performed. Patients undergoing elective left sided colonic or rectal resection with primary anastomosis between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary outcome measure was anastomotic leak. Results: Of 3676 patients across 343 centres in 47 countries, 618 (16.8%) received MBP+ABx, 1945 MBP (52.9%) and 1099 patients NBP (29.9%). Patients undergoing MBP+ABx had the lowest overall rate of anastomotic leak (6.1%, 9.2%, 8.7% respectively) in unadjusted analysis. After case-mix adjustment using a mixed-effects multivariable regression model, MBP+Abx was associated with a lower risk of anastomotic leak (OR 0.52, 0.30-0.92, P = 0.02) but MBP was not (OR 0.92, 0.63-1.36, P = 0.69) compared to NBP. Conclusion: This non-randomised study adds &apos;real-world&apos;, contemporaneous, and prospective evidence of the beneficial effects of combined mechanical bowel preparation and oral antibiotics in the prevention of anastomotic leak following left sided colorectal resection across diverse settings. We have also demonstrated limited uptake of this strategy in current international colorectal practice. Colorectal Disease (C) 2018 The Association of Coloproctology of Great Britain and Ireland

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

—

Continuities

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Colorectal Disease

ISSN

1462-8910

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

Supplement 6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

18

Pages from-to

15-32

UT code for WoS article

000445602400005

EID of the result in the Scopus database

2-s2.0-85053817875