Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis-Clinical Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F19%3A10398834" target="_blank" >RIV/00179906:_____/19:10398834 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/19:10398834
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=BIIhSV8I3D" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=BIIhSV8I3D</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijerph16193698" target="_blank" >10.3390/ijerph16193698</a>
Alternative languages
Result language
angličtina
Original language name
Hyaluronic Acid-Based Medical Device for Treatment of Alveolar Osteitis-Clinical Study
Original language description
Alveolar Osteitis (AO) is a complication following the extraction of a tooth. AO manifests through localized pain in, and around, the extraction site, where the post-operative blood clot has been disintegrated. The aim of this single cohort study was to evaluate the outcome of a treatment of AO, using a pharmacological device composed of hyaluronic acid and octenidine dihydrochloride. The tested device is a sponge-like material, composed solely of a fully dissoluble medicaments (hyaluronic acid, calcium chloride, and octenidine dihydrochloride). It was designed to serve as a non-toxic, slow-dissolving antiseptic, that adheres to mucosa and obturates the wound. This study includes 58 subjects who were diagnosed with AO. The tested device was administered once daily until local pain subsided to < 20 mm of the Visual Analog Scale (VAS). The treatment was considered effective when the pain subsided to < 20 mm VAS in < 8 days of treatment; as per comparative studies. Our findings provide a statistically significant success rate of 96.0% (95.0% confidence interval of 75.75% to 97.8%) after pharmacological device administrations. No adverse medical effects were detected. Acquired data confirmed that lyophilized hyaluronic acid, combined with octenidine, is effective for the treatment of AO. The results are clinically important as AO is a common complication after third molar extractions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30208 - Dentistry, oral surgery and medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Environmental Research and Public Health
ISSN
1660-4601
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
19
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
3698
UT code for WoS article
000494748600194
EID of the result in the Scopus database
2-s2.0-85072912138