Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F19%3A10402164" target="_blank" >RIV/00179906:_____/19:10402164 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/19:10402164
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JrpMzyjJc3" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=JrpMzyjJc3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2019/5371381" target="_blank" >10.1155/2019/5371381</a>
Alternative languages
Result language
angličtina
Original language name
Investigation of 23 Bile Acids in Liver Bile in Benign and Malignant Biliary Stenosis: A Pilot Study
Original language description
Differential diagnosis between benign and malignant biliary stenosis can be difficult in clinical practice. Histology of biopsy specimens is often indeterminate. Laboratory markers (serum bilirubin > 75 μmol/L, carbohydrate antigen 19-9 > 400 U/mL) and the length of stenosis (>15mm) can be helpful but are not specific enough. The aim of this study was to investigate bile acids in liver bile of patients with benign and malignant biliary stenosis and controls without stenosis. A total of 73 patients entered the study: 7 subjects with benign biliary stenosis (6 men, 1 woman; 68 +- 13 years old), 21 with malignant biliary stenosis (15 men, 6 women; 72 +- 14 years old), and 45 patients without biliary stenosis (22 men, 23 women; 70 +- 13 years old); out of those, 25 subjects have and 20 do not have choledocholithiasis. Twenty-three different bile acids were investigated by highperformance liquid chromatography/mass spectrometry. Serum total bilirubin was significantly higher in patients with malignant biliary stenosis compared with nonstenotic controls (p = 0:005). Significant relationship (r > 0:7) was found between several pairs of bile acids. Significantly lower bile acid concentrations in malignant biliary stenosis compared to controls without stenosis were found for GLCA (p = 0:032), GUDCA (p = 0:032), GCDCA (p = 0:006), GDCA (p = 0:031), GHCA (p = 0:005), TUDCA (p = 0:044), and TDCA (p = 0:036). ignificant difference in cholic acid was found between benign and malignant stenosis (p = 0:022). Analysis of bile acids might be helpful in the differential diagnosis of malignant and benign biliary stenosis. More patients need to be enrolled in further studies so that the real diagnostic yield of bile acids can be determined.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30219 - Gastroenterology and hepatology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Gastroenterology Research and Practice
ISSN
1687-6121
e-ISSN
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Volume of the periodical
2019
Issue of the periodical within the volume
Spec. Iss.
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
5371381
UT code for WoS article
000521586800001
EID of the result in the Scopus database
2-s2.0-85077430903