Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F22%3A10446725" target="_blank" >RIV/00179906:_____/22:10446725 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/22:50019183
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lPrb5aR5BA" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lPrb5aR5BA</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/med.21892" target="_blank" >10.1002/med.21892</a>
Alternative languages
Result language
angličtina
Original language name
Small-molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria-related diseases
Original language description
Cyclophilin D (CypD) is a key regulator of mitochondrial permeability transition pore (mPTP) opening. This pathophysiological phenomenon is associated with the development of several human diseases, including ischemia-reperfusion injury and neurodegeneration. Blocking mPTP opening through CypD inhibition could be a novel and promising therapeutic approach for these conditions. While numerous CypD inhibitors have been discovered to date, none have been introduced into clinical practice, mostly owing to their high toxicity, unfavorable pharmacokinetics, and low selectivity for CypD over other cyclophilins. This review summarizes current knowledge of CypD inhibitors, with a particular focus on small-molecule compounds with regard to their in vitro activity, their selectivity for CypD, and their binding mode within the enzyme's active site. Finally, approaches for improving the molecular design of CypD inhibitors are discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Medicinal Research Reviews
ISSN
0198-6325
e-ISSN
1098-1128
Volume of the periodical
42
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
34
Pages from-to
1822-1855
UT code for WoS article
000795933400001
EID of the result in the Scopus database
2-s2.0-85132598116