MRI-based adaptive radiotherapy has the potential to reduce dysphagia in patients with head and neck cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F23%3A10454385" target="_blank" >RIV/00179906:_____/23:10454385 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/24:00558879
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oltdVfL~.X" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=oltdVfL~.X</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ejmp.2022.12.003" target="_blank" >10.1016/j.ejmp.2022.12.003</a>
Alternative languages
Result language
angličtina
Original language name
MRI-based adaptive radiotherapy has the potential to reduce dysphagia in patients with head and neck cancer
Original language description
Purpose: This study explored the potential of MRI-based adaptive radiotherapy to spare dysphagia and aspiration related structures (DARS) in a heterogeneous cohort of patients (n = 23) who received radiotherapy (RT) for different sites of head and neck cancer. Methods: Pharyngeal constrictor muscles (PCM), cricopharyngeal muscle (CPM), proximal part of the esophagus (PE), supraglottic larynx (SGL), and transglottic larynx (TGL) were contoured in weekly MRI during the treatment and considered as DARS. To compare dysphagia-optimized radiotherapy (DORT) and MRI-based dysphagiaoptimized adaptive radiotherapy (DOART), two data sets were created for each patient using synthetic CTs created by deforming the initial planning CT. Dose-volume histograms (DVHs) of accumulated doses were generated and dosimetric parameters V50Gy - V70Gy and mean doses were measured for DARS and for both DORT and DOART. Results: The significant improvements in DARS-sparing were observed in regions of the highest doses (95% confidence interval, p < 0.05). For example, V70Gy in PCM decreased from 7.8 +- 5.5% to 2.6 +- 4.4% - this was a reduction by 67% (p < 0.001). Similarly, the relative decreases of V65 Gy in PCM, V60 Gy in SGL, V60 Gy in TGL, and V55 Gy in CPM were 37%, 32%, 46%, and 27%, respectively. Conclusions: It was shown that MRI-based DOART has the potential to significantly reduce the radiation burden of DARS as a response to the decreasing volume of primary tumor or lymphatic nodes. Findings of this study provide novel evidence to suggest that the concept of MRI-based DOART could contribute to spare DARS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30224 - Radiology, nuclear medicine and medical imaging
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physica Medica
ISSN
1120-1797
e-ISSN
1724-191X
Volume of the periodical
105
Issue of the periodical within the volume
JAN
Country of publishing house
IT - ITALY
Number of pages
10
Pages from-to
102511
UT code for WoS article
000911094600001
EID of the result in the Scopus database
2-s2.0-85145689760