A comprehensive assessment of lymphocyte subsets, their prognostic significance, and changes after first-line therapy administration in patients with chronic lymphocytic leukemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F23%3A10454718" target="_blank" >RIV/00179906:_____/23:10454718 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/23:10454718
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lsx0zY-lok" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=lsx0zY-lok</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cam4.5492" target="_blank" >10.1002/cam4.5492</a>
Alternative languages
Result language
angličtina
Original language name
A comprehensive assessment of lymphocyte subsets, their prognostic significance, and changes after first-line therapy administration in patients with chronic lymphocytic leukemia
Original language description
Background: In chronic lymphocytic leukemia (CLL), changes in the peripheral blood lymphocyte subsets play an important role in disease progression and infectious complications. The impact of chemoimmunotherapy (CIT) on these changes has not been extensively studied Methods: We used multi-color flow cytometry, to prospectively measure absolute and relative numbers of CD4(+) and CD8(+) T-cells and their subsets in 45 patients with indolent untreated CLL, 86 patients indicated for first-line treatment, and 34 healthy controls. In 55 patients, we analyzed the impact of CIT Results: CLL patients had a significant increase in most cell populations in comparison to controls. Progression of CLL was characterized by significantly elevated counts with the exception of a lower percentage of naive T-cells. After treatment, the percentage of naive T-cells further decreased at the expense of effector memory T-cells (TEM). In patients with indolent CLL, higher percentages of naive CD4(+) (p = 0.0026) and naive CD8(+) (p = 0.023) T-cells were associated with a longer time to first treatment (TTFT). The elevation of CD4(+) central memory T-cells (TCM) (p = 0.27) and TEM (p = 0.003) counts and a higher percentage of CD4(+) TEM (p = 0.0047), were linked with shorter TTFT. In treated patients, increased regulatory T-cells count was associated with shorter time to next treatment (TTNT) (p = 0.042), while higher CD4(+) TCM count with shorter TTNT (p = 0.035) and shorter overall survival (p = 0.041). Conclusion: Our results indicate that naive cell depletion and CD4(+) TCM and TEM increases are detrimental to CLL patients' prognosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30205 - Hematology
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancer Medicine
ISSN
2045-7634
e-ISSN
2045-7634
Volume of the periodical
12
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
15
Pages from-to
6956-6970
UT code for WoS article
000891193500001
EID of the result in the Scopus database
2-s2.0-85148372598