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Outcomes of Mechanical Thrombectomy of Acute Basilar Artery Occlusion Due to Underlying Intracranial Atherosclerotic Disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F23%3A10455447" target="_blank" >RIV/00179906:_____/23:10455447 - isvavai.cz</a>

  • Result on the web

    <a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=qBWlvDg.mj" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=qBWlvDg.mj</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1161/SVIN.122.000429" target="_blank" >10.1161/SVIN.122.000429</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Outcomes of Mechanical Thrombectomy of Acute Basilar Artery Occlusion Due to Underlying Intracranial Atherosclerotic Disease

  • Original language description

    Background: Intracranial atherosclerotic disease (ICAD) is a common cause of posterior circulation acute ischemic stroke. We aimed to compare baseline characteristics, recanalization rates, and clinical outcomes in patients with acute basilar occlusion due to underlying ICAD to patients with other causes of occlusion. Methods: The Trevo Registry (ClinicalTrials.gov Identifier: NCT02040259) was a prospective open-label mechanical thrombectomy registry that included 2008 patients from 76 sites across 12 countries. For a secondary analysis, we selected patients with isolated acute basilar occlusion. We then classified patients into 2 groups: patients with acute basilar artery occlusion due to ICAD (ICAD group) and patients with acute basilar occlusion due to another cause (non-ICAD group). Results: We identified 90 subjects with acute basilar occlusion. According to stroke mechanism, there were 9 (10.0%) patients in the ICAD group and 81 (90.0%) in the non-ICAD group. There was a significant difference (P=0.001) in the lesion location between the 2 groups, with 60.5% of non-ICAD occlusions located in the distal region and no ICAD occlusions there. The 2 groups showed a significant difference (P=0.003) for rescue therapy with balloon angioplasty, with 33.3% in the ICAD group and 1.2% in the non-ICAD group, respectively. In a multivariable model adjusted for age, baseline National Institutes of Health Stroke Scale, and intravenous tissue-type plasminogen activator (tPA), the odds of 90-day death (odds ratio=4.6; P=0.10) were higher for atherosclerotic subjects. Conclusion: Acute basilar occlusions related to ICAD showed a similar good clinical outcome (modified Rankin scale (mRS) 0-2) and a tendency for a higher rate of 90-day mortality compared with non-ICAD occlusions.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30224 - Radiology, nuclear medicine and medical imaging

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Stroke: Vascular and Interventional Neurology

  • ISSN

    2694-5746

  • e-ISSN

    2694-5746

  • Volume of the periodical

    3

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    e000429

  • UT code for WoS article

    001151798300005

  • EID of the result in the Scopus database