Lipid emulsions prevent postoperative abdominal adhesions

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F23%3A10458630" target="_blank" >RIV/00179906:_____/23:10458630 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11150/23:10458630 RIV/60162694:G44__/24:00558853

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=eUC5SBCUr2" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=eUC5SBCUr2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.asjsur.2022.05.119" target="_blank" >10.1016/j.asjsur.2022.05.119</a>

Result language

angličtina

Original language name

Lipid emulsions prevent postoperative abdominal adhesions

Original language description

Introduction: Adhesions are the most common cause of long-term morbidity after abdominal surgery and most often cause various forms of intestinal passage disorders ranging from partial obstruction to complete, life-threatening intestinal obstruction. The aim of the present study was to evaluate the protective effect of intraperitoneally administered lipid emulsions on the formation of adhesions in larger animal model, as the lubricating effect of phospholipids and the mechanical barrier of the lipid component are combined with the anti-inflammatory effect of fish oil. Methods: Thirty-one female domestic pigs were randomly divided into three groups. At the end of the surgical procedure, a lipid emulsion or saline solution was applied intraperitoneally. After 14 days, an independent macroscopic, histological and immunohistochemical evaluation of the adhesions were performed. Results: Intraperitoneal administration of lipid emulsions significantly reduced the incidence of intra-abdominal adhesions. Microscopic examination demonstrated a significant reduction in the number of inflammatory elements and the amount of collagen in the adhesions, especially after administration of the fish oil-based emulsion. A simultaneous decrease in neovascularization was observed in the adhe-sions. Evaluation of the intestinal anastomosis did not reveal significant differences in healing between the groups. Conclusion: Intraperitoneal administration of lipid emulsions can reduce the development of post-operative intra-abdominal adhesions by the combined action of phospholipids as important lubricants and lipids as a mechanical barrier. Their effect is caused by a reduction in proinflammatory and profi-brotic mediators. At the same time, intraperitoneal administration of lipid emulsions does not impair healing of the anastomosis in larger animal model.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30212 - Surgery

Project

—

Continuities

—

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Asian Journal of Surgery

ISSN

1015-9584

e-ISSN

0219-3108

Volume of the periodical

46

Issue of the periodical within the volume

1

Country of publishing house

CN - CHINA

Number of pages

7

Pages from-to

465-471

UT code for WoS article

000908065500030

EID of the result in the Scopus database

2-s2.0-85131421676