Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F23%3A10471255" target="_blank" >RIV/00179906:_____/23:10471255 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G44__/24:00560706 RIV/62690094:18470/23:50020765 RIV/00216208:11160/23:10471255
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4cIS~Oo-UR" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=4cIS~Oo-UR</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cbi.2023.110735" target="_blank" >10.1016/j.cbi.2023.110735</a>

Result language
angličtina
Original language name
Sustainable ionic liquids-based molecular platforms for designing acetylcholinesterase reactivators
Original language description
We report a green chemistry approach for preparation of oxime-functionalized ILs as AChE reactivators: amide/ester linked IL, L-alanine, and L-phenylalanine derived salts bearing pyridinium aldoxime moiety. The reactivation capacities of the novel oximes were evaluated towards AChE inhibited by typical toxic organophosphates, sarin (GB), VX, and paraoxon (PON). The studied compounds are mostly non-toxic up to the highest concentrations screened (2 mM) towards Gram-negative and Gram-positive bacteria cell lines and both filamentous fungi and yeasts in the in vitro screening experiments as well as towards the eukaryotic cell (CHO-K1 cell line). Introduction of the oxime moiety in initially biodegradable structure decreases its ability to biodegradation. The compound 3d was shown to reveal remarkable activity against the AChE inhibited by VX, exceeding conventional reactivators 2-PAM and obidoxime. The regularities on antidotal activity, cell viability, plasma stability, biodegradability as well as molecular docking study of the newly synthesized oximes will be used for further improvement of their structures.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/GA22-12859S" target="_blank" >GA22-12859S: Novichok nerve agents - toxicity and countermeasures</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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