Glycemic control by treatment modalities: national registry-based population data in children and adolescents with type 1 diabetes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10464587" target="_blank" >RIV/00179906:_____/24:10464587 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10464587 RIV/00216208:11120/24:43926185 RIV/00216208:11130/24:10464587 RIV/00216208:11320/24:10464587 and 5 more
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=y~nzINPD5z" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=y~nzINPD5z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000530833" target="_blank" >10.1159/000530833</a>
Alternative languages
Result language
angličtina
Original language name
Glycemic control by treatment modalities: national registry-based population data in children and adolescents with type 1 diabetes
Original language description
AIMSTo assess the differences in key parameters of type 1 diabetes (T1D) control associated with treatment and monitoring modalities including newly introduced hybrid closed-loop (HCL) algorithm in children and adolescents with T1D (CwD) using the data from the population-wide pediatric diabetes registry CENDA. MATERIALS AND METHODSCwD younger than 19 years with T1D duration > 1 year were included and divided according to the treatment modality and type of CGM used: multiple daily injection (MDI), insulin pump without (CSII) and with HCL function, intermittently scanned continuous glucose monitoring (isCGM), real-time CGM (rtCGM), and intermittent or no CGM (noCGM). HbA1c, times in glycemic ranges, and glucose risk index (GRI) were compared between the groups.RESULTSData of a total of 3251 children (mean age 13.4 +/- years) were analyzed. 2187 (67.3%) were treated with MDI, 1064 (32.7%) with insulin pump, 585/1064 (55%) with HCL. The HCL users achieved the highest median TIR 75.4% (IQR 6.3), and GRI 29.1 (7.8), both p<0.001 compared to other groups, followed by MDI rtCGM and CSII groups with TIR 68.8% (IQR 9.0) and 69.0% (7.5), GRI 38.8 (12.5) and 40.1 (8.5), respectively (non-significant to each other). These three groups did not significantly differ in their HbA1c medians (51.8 (IQR 4.5), 50.7 (4.5), and 52.7 (5.7) mmol/mol, respectively). NoCGM groups had the highest HbA1c and GRI and lowest TIR regardless of the treatment modality.CONCLUSIONSThis population-based study shows that the HCL technology is superior to other treatment modalities in CGM-derived parameters and should be considered as a treatment of choice in all CwD fulfilling the indication criteria.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30209 - Paediatrics
Result continuities
Project
<a href="/en/project/NU21-01-00085" target="_blank" >NU21-01-00085: Low-carbohydrate diet in type 1 diabetes: effects on glycemic control and islet autoimmunity</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Hormone Research in Paediatrics
ISSN
1663-2818
e-ISSN
1663-2826
Volume of the periodical
97
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
10
Pages from-to
70-79
UT code for WoS article
000976877900001
EID of the result in the Scopus database
2-s2.0-85175380833