Capillary zone electrophoresis method for quantification of therapeutic peptide glatiramer acetate

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10481213" target="_blank" >RIV/00179906:_____/24:10481213 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/24:10481213 RIV/61989592:15310/24:73627472
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=HV3wRzuXXI" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=HV3wRzuXXI</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00706-024-03190-8" target="_blank" >10.1007/s00706-024-03190-8</a>

Result language
angličtina
Original language name
Capillary zone electrophoresis method for quantification of therapeutic peptide glatiramer acetate
Original language description
This study presents the development and validation of a novel capillary zone electrophoresis method for the precise determination of glatiramer acetate and its amino acid constituents. A 120 mmol dm-3 phosphoric acid solution adjusted to pH 1.9 with Tris, supplemented with 20 mmol dm-3 triethylamine to achieve a final of pH 2.1, resulted in a repeatable analysis of glatiramer acetate. The method demonstrated a limit of detection and quantification of 39.2 mu g cm-3 and 130.7 mu g cm-3, respectively. This method allows for the rapid control of glatiramer acetate-based pharmaceuticals and distinguishes glatiramer acetate from the amino acids used in its synthesis.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30100 - Basic medicine

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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