Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F24%3A10484168" target="_blank" >RIV/00179906:_____/24:10484168 - isvavai.cz</a>

Alternative codes found

RIV/62690094:18470/24:50021583

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.0r1LQQaGl" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=.0r1LQQaGl</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cbi.2024.111138" target="_blank" >10.1016/j.cbi.2024.111138</a>

Result language

angličtina

Original language name

Quantification of oxidative stress markers in the blood sera following subacute administration of different oximes in rats

Original language description

Oxidative stress status, as a disruption of redox homeostasis, in the blood sera of Wistar rats caused by repeated application of selected acetylcholinesterase reactivators- asoxime, obidoxime, K027, K048, K074, and K075 were evaluated. Throughout this study, each oxime in a dose of 0.1 of LD 50 /kg im was given 2x/week for 4 weeks. Then, seven days after the last oximes &apos; application, markers of lipid peroxidation (malondialdehyde, MDA), and protein oxidation (advanced oxidation protein products, AOPP), as well as the activity of antioxidant enzymes (catalase, CAT, superoxide dismutase, SOD, reduced glutathione, GSH, and oxidized glutathione, GSSG), were determined. Oxidative stress parameters, MDA and AOPP were significantly highest in the K048-, K074- and K075-treated groups ( p &lt; 0.001). The activity of CAT was significantly elevated in the obidoximetreated group ( p &lt; 0.05), while treatment with K027, K048, and K074 induced high elevation in SOD levels ( p &lt; 0.01, p &lt; 0.001). Interestingly, the activity of GSH in each oxime-treated group was significantly elevated. Unlike, treatment with obidoxime caused elevation in GSSG levels ( p &lt; 0.01). As a continuation of our previously published data, these results assure that applied oximes following subacute treatment ameliorated the oxidative status and further adverse systemic toxic effects in rats.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemico-Biological Interactions

ISSN

0009-2797

e-ISSN

1872-7786

Volume of the periodical

399

Issue of the periodical within the volume

AUG

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

9

Pages from-to

111138

UT code for WoS article

001272683000001

EID of the result in the Scopus database

2-s2.0-85198293401