Anticholinesterases Traits Inbuilt in Buxaceae Plant Extracts against Alzheimer's Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10499957" target="_blank" >RIV/00179906:_____/25:10499957 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G45__/26:00564889 RIV/60076658:12110/25:43910247 RIV/62690094:18470/25:50022484 RIV/00216208:11310/25:10499957 RIV/61989100:27360/25:10258204
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nMofSK-21a" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=nMofSK-21a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1570159X23666250326091016" target="_blank" >10.2174/1570159X23666250326091016</a>
Alternative languages
Result language
angličtina
Original language name
Anticholinesterases Traits Inbuilt in Buxaceae Plant Extracts against Alzheimer's Disease
Original language description
This review provides a comprehensive account of advances in the field of cholinesterase inhibitors isolated from the Buxaceae family. Naturally occurring anticholinesterases derived from plants are considered to be a potential source of new drug candidates for treating Alzheimer's disease (AD). AD is now universally accepted as an irreversible, incurable, and progressive neurological disorder. Initiating with memory impairment, propagating with cognitive deficit, and ultimately leading to death is the general pathway of AD. Lower level of acetylcholine in the brain is characterized as one of the prominent reasons for AD. The cholinergic hypothesis states that elevated levels of acetylcholine in the brain can alleviate symptoms of AD. Steroidal and terpenoidal alkaloids isolated from plants of the Buxaceae family have been reviewed here for their anticholinesterase activity. Most of them have shown in vitro inhibition of horse serum butyrylcholinesterase (BuChE, EC 3.1.1.7) and electric eel acetylcholinesterase (AChE, EC 3.1.1.8). Although the general consensus has concluded that cholinesterase inhibitors may alleviate AD symptoms but cannot cure the disease, new drugs are still being sought to improve the quality of life of AD patients. Steroidal and terpenoidal anticholinesterase alkaloids can prove to be a promising group of AChE inhibitors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Neuropharmacology
ISSN
1570-159X
e-ISSN
1875-6190
Volume of the periodical
23
Issue of the periodical within the volume
10
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
19
Pages from-to
1137-1155
UT code for WoS article
001526823800007
EID of the result in the Scopus database
2-s2.0-105010650621