Protection of the Endothelium and Endothelial Glycocalyx by Albumin and Sulodexide in Porcine Model of Kidney Transplant

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00179906%3A_____%2F25%3A10503473" target="_blank" >RIV/00179906:_____/25:10503473 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24530/25:00014643 RIV/00216208:11150/25:10503473

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GJ4wP.JYho" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=GJ4wP.JYho</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.6002/ect.2024.0222" target="_blank" >10.6002/ect.2024.0222</a>

Result language

angličtina

Original language name

Protection of the Endothelium and Endothelial Glycocalyx by Albumin and Sulodexide in Porcine Model of Kidney Transplant

Original language description

Objectives: Kidney transplant is a life-saving procedure for patients with end-stage renal disease. Success of kidney transplant is highly dependent on maintaining the integrity of the endothelium and its protective layer, the endothelial glycocalyx. Ischemia-reperfusion injury, a common challenge in kidney transplant, can disrupt the endothelial glycocalyx, leading to various post-transplant complications. We investigated the effects of albumin and sulodexide, 2 therapeutic agents, for protection of the endothelium and endothelial glycocalyx in a porcine model of kidney transplant. Materials and Methods: Fourteen female piglets were prepared for kidney transplant simulation and randomly divided into 3 groups: a control group, an albumin-treated group, and a sulodexide-treated group. Various physiological parameters were monitored, and samples for serum and urine were collected at baseline and at multiple time points after reperfusion. Integrity of the endothelial glycocalyx was assessed from serum syndecan-1 levels and urinary glycosaminoglycan concentrations. Histology of the renal cortex allowed evaluation of tissue changes following the intervention. Results: Statistically significant differences were observed in the sulodexide-treated group, where serum syndecan-1 levels were lower versus the control group at 5 minutes after reperfusion (P = .046), indicating a potential reduction in endothelial glycocalyx damage. Similarly, in the albumin-treated group, urinary glycosaminoglycan levels were significantly lower versus the control group at 5 minutes after reperfusion (P = .041), which may suggest a protective effect on the endothelial glycocalyx. However, these findings are preliminary, and no other significant differences were detected between the treatment groups and the control group at later time points. Histology of the renal cortex revealed that the changes were generally minor across all groups. Conclusions: We suggest that albumin and sulodexide may offer beneficial effects in preserving endothelial function during kidney transplant. The potential for these agents to enhance graft survival and improve kidney transplant outcomes warrants further investigation.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30213 - Transplantation

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental and Clinical Transplantation

ISSN

1304-0855

e-ISSN

2146-8427

Volume of the periodical

23

Issue of the periodical within the volume

8

Country of publishing house

TR - TURKEY

Number of pages

8

Pages from-to

509-516

UT code for WoS article

001567300500001

EID of the result in the Scopus database

2-s2.0-105015709022